Iron, platelet function, and coronary heart disease: a possible link?

Fibrinogen: a possible link between social class and coronary heart disease.

Mortality from coronary heart disease in civil servants in the lowest grade of employment has been found to be about three times that of men in the highest grade of employment. As part of an investigation of this finding several haemostatic variables were measured in a sample of 29 men in lower grades of employment and 45 men in higher grades. There was a significant difference in plasma fibrin...

Body iron stores and coronary heart disease.

Over the past 20 years, the hypothesis that body iron stores are associated with risk of coronary heart disease (CHD) has generated extensive debate (1–4). This debate has intensified in the last 4 years after reports from three studies that carriers of the recently discovered HFE C282Y mutation commonly seen in hereditary hemochromatosis have significantly increased risk of CHD (5–9). Clinical...

Testosterone and coronary heart disease: is there a link?

Platelet function studies in coronary artery disease.

Platelets have been implicated and abnormal platelet function proposed in the pathogenesis of coronary artery disease (CAD). This investigation examines platelet function in men with stable, arteriographically defined CAD and correlates results with lipid pattern, history of angina or 'myocardial infarction and smoking habits. Platelet survival (51Chromium method), adhesiveness, and aggregation...

Iron levels in coronary heart disease patients without known risk factors

Background: Coronary heart disease is a common disease after adolescence. Strong epidemiological evidence is available that iron is an important factor in coronary artery disease. Therefore this study was done to assess the relationship between iron stores and coronary artery disease. Materials and methods: 208 subjects with cardiovascular disease were included in the study. Personal informati...